Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial

Electrochemotherapy in cancer patients: first clinical trial in Greece.

Electrochemotherapy is currently undergoing intensive investigation in the field of local control of cancer. In Greece, five medical centers have co-operated to perform ECT for the efficient management of growing, recurrent or newly emerging cutaneous and subcutaneous tumor nodules. ECT was applied alone or in combination with external beam radiation therapy, brachytherapy and surgery in 52 can...

Intravitreal sirolimus for the treatment of geographic atrophy: results of a phase I/II clinical trial.

PURPOSE To investigate the safety and effects of intravitreal sirolimus for the potential treatment of geographic atrophy (GA). METHODS The study was a single-center, open-label, phase I/II trial enrolling six participants with bilateral GA treated with intravitreal sirolimus in only one randomly assigned eye, with the fellow eye as control. The primary efficacy outcome measure was the change...

Phase I Clinical Trial Design

Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice.

One of the ways to increase drug delivery into cells and tissues is by a local application of short, intense electric pulses, i.e., electropermeabilization. This approach is used in electrochemotherapy to potentiate antitumor effectiveness of chemotherapeutic drugs. To determine whether electropermeabilization can potentiate antitumor effectiveness of cis-diamminedichloroplatinum(II) (CDDP), el...

Treatment of intraoral ranulas with micromarsupialization: clinical outcomes and safety from a phase II clinical trial.

BACKGROUND Micromarsupialization of an oral ranula has been introduced to clinical practice. However, the technical feasibility, indications, and safety of the procedure were not fully studied. In this study, we report the results of a prospective phase II clinical trial to evaluate the clinical outcomes. METHODS Twenty patients diagnosed with oral ranula were enrolled in this trial. The ranu...